Monday, August 8, 2011

Mr Lee, a hemophilic, has a daughter of normal phenotype. Mr Lee’s daughter marries?

Hemophilia is an X linked recessive disorder. Since the daughter received one X chromosome from her father, she would be a heterozygote, or Hh. In other words, she has one dominant and one recessive gene. I don't think I can draw a Punnett square with a word processor. The man who is normal and marries the daughter must not be recessive. He only has one X chromosome, so his genotype is H. If the two have a daughter, she will receive the man's dominant H gene, and either of the genes from the mother. The daughter will have a 50% chance of being HH, and 50% of being Hh. Neither will give her the phenotype.

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